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KMID : 0359320220620040005
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Korean Journal of Veterinary Research
2022 Volume.62 No. 4 p.5 ~ p.5
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Primary copper-associated chronic hepatitis without copper metabolism domain containing 1 mutation in a Dalmatian: a case report
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Yun Su-Min
Lee Do-Hee
Oh Ji-Min
Chae Yeon
Yun Tae-Sik
Koo Yoon-Hoi
Yang Mhan-Pyo
Kang Byeong-Teck
Kim Hak-Hyun
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Abstract
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A 12-year-old intact male Dalmatian dog presented hyporexia and vomiting for 1 week. Blood analysis revealed increased liver enzyme activity. Histopathological examination of the liver confirmed chronic hepatitis with fibrosis and necrosis. Copper staining revealed marked copper accumulation (2,770 ppm; normal range, 200 to 400 ppm), prominent in the centrilobular region, and compatible with copper-associated chronic hepatitis. However, copper metabolism domain containing 1 (COMMD1) mutation predisposing to copper accumulation in the liver tissue was not identified. The dog received medications but died 1 month after first visit. This is the first case of primary copper-associated hepatitis without COMMD1 mutation in a Dalmatian dog in South Korea.
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KEYWORD
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dogs, liver, penicillamine, rhodanine
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